Optimized response-adaptive clinical trials : sequential treatment allocation based on Markov decision problems / Thomas Ondra.
Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial desi...
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Full Text (via Springer) |
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| Main Author: | |
| Format: | eBook |
| Language: | English |
| Published: |
Wiesbaden :
Springer Spektrum,
2015.
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| Series: | BestMasters.
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| Subjects: |
Table of Contents:
- Introduction to Markov Decision Problems and Examples
- Finite and Infinite Horizon Markov Decision Problems
- Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration
- Designing Response Adaptive Clinical Trials with Markov Decision Problems.