Isolation and characterization of Agouti [electronic resource] : a diabetes/obesity related gene.
Isolation; Characterization; Agouti; Diabetes; Obesity; Related; Relates; Cloning; Expression; Agouti; Analogous; Genes; Transformed; Transfected; Transgenic; Mice; Provides; Animal; Model; Study; Diabetes; Obesity; Tumors; Testing; Potential; Therapeutic; Agents; Provides; Oligonucleotide; Probes;...
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Online Access |
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| Format: | Government Document Electronic eBook |
| Language: | English |
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Oak Ridge, Tenn. : Oak Ridge, Tenn. :
Oak Ridge National Laboratory. ; distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
1998.
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| Summary: | Isolation; Characterization; Agouti; Diabetes; Obesity; Related; Relates; Cloning; Expression; Agouti; Analogous; Genes; Transformed; Transfected; Transgenic; Mice; Provides; Animal; Model; Study; Diabetes; Obesity; Tumors; Testing; Potential; Therapeutic; Agents; Provides; Oligonucleotide; Probes; Detection; Agouti; Mutations; Relates; Isolation; Recombinant; Production; Agouti; Product; Production; Antibodies; Agouti; Product; Diagnostic; Therapeutic; Agents; Oligonucleotide Probes; Therapeutic Agents; Therapeutic Agents; Recombinant Production; Provides Oligonucleotide; Transgenic Mice; Therapeutic Agent; Therapeutic Agent; Animal Model; Analogous Genes; Potential Therapeutic; Obesity Related; Oligonucleotide Probe. |
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| Abstract: | The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents. |
| Item Description: | Published through SciTech Connect. 01/01/1998. "us 5843652" Woychik, Richard P. |