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Stem cells : basics and clinical translation / Robert Chunhua Zhao, editor.

This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of...

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Bibliographic Details
Online Access: Full Text (via Springer)
Other Authors: Zhao, Robert Chunhua (Editor)
Format: eBook
Language:English
Published: Shanghai : Dordrecht : Shanghai Jiao Tong University Press ; Springer, [2015]
Series:Translational medicine research.
Subjects:
Stem cells > Research.

MARC

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504 |a Includes bibliographical references. 
505 0 |a Series Foreword; Preface; Contents; Part I Basic Concepts of Stem Cells; 1 Primordial Germ Cells and Germ Line Stem Cells ; Abstract ; 1.1 The Origin and Fate of Germ Cells in Mammals; 1.1.1 PGC Specification in Mammals; 1.1.2 PGC Migration in Mammals; 1.1.3 PGC Development in Mammals; 1.2 Female Germ Line Stem Cells; 1.2.1 Introduction; 1.2.2 History of FGSC Research; 1.2.3 Current FGSC Research Progress; 1.2.3.1 FGSC Origin and Their Location; 1.2.3.2 FGSC Isolation and Culture; 1.2.3.3 FGSC Characterization; 1.2.3.4 FGSC Transplantation; 1.2.4 Applications of FGSCs. 
505 8 |a 1.3 Spermatogonial Stem Cells1.3.1 Introduction; 1.3.2 SSC Properties; 1.3.2.1 SSC Classification; 1.3.2.2 SSC Characteristics; 1.3.2.3 Reversibility and Heterogeneity; 1.3.3 SSC Niche; 1.3.4 Fate Decisions of SSCs; 1.4 Perspectives; References; 2 Human Amniotic Fluid-Derived and Amniotic Membrane-Derived Stem Cells ; Abstract ; 2.1 Amniotic Membrane and Amniotic Fluid; 2.2 Isolation and Culture; 2.2.1 AMSCs and AECs; 2.2.2 AFSCs; 2.3 Identification and Characterization; 2.4 Function Features; 2.4.1 Plasticity In Vivo; 2.4.2 Immunomodulation; 2.4.3 Epithelial-Mesenchymal Transition (EMT) 
505 8 |a 2.4.4 Angiogenic Potential2.4.5 Secretion Function; 2.5 The Potential Applications and Therapeutic Base; 2.5.1 Cardiac Regeneration; 2.5.2 Neuronal Regeneration; 2.5.3 Liver Disease; 2.5.4 Kidney Injury; 2.5.5 Skin Wounds and Burns; 2.5.6 Autoimmune Disease; 2.5.7 Premature Ovarian Failure; 2.5.8 Hematopoietic Supporting and Improvement; 2.5.9 Eye Injury; 2.5.10 Other Tissue Injury; 2.5.11 Potential Antitumor Therapeutic Strategies; 2.5.12 The Challenge of Clinical Translation; References; 3 Mesenchymal Stem Cells and Their Immunomodulatory Properties ; Abstract ; 3.1 Introduction. 
505 8 |a 3.2 Characteristics of MSC3.3 MSCs Exert Their Immunomodulation Function by Different Mechanisms; 3.3.1 The Interaction Between MSCs and T Cells; 3.3.2 The Interactions Between MSCs and Antigen-Presenting Cells; 3.3.3 The Interaction Between MSCs and B Cells; 3.3.4 Interaction Between MSCs and Natural Killer Cells; 3.3.5 MSCs Survive and Induce Immune Tolerance in the Host; 3.4 Applications of MSCs; 3.4.1 GVHD; 3.4.2 Organ Transplantation; 3.4.3 Chronic Inflammatory Autoimmune Diseases; 3.4.4 Conclusions and Future Directions; References. 
505 8 |a 4 Induced Pluripotent Stem Cell, a Rising Star in Regenerative Medicine Abstract ; 4.1 Introduction; 4.2 Characteristics of iPSCs; 4.3 Development of iPS Technology and Theory; 4.4 Potential Application of iPSCs in Disease Treatment; 4.4.1 iPSCs and Hematological Diseases; 4.4.1.1 Sickle Cell Anemia; 4.4.1.2 Hemophilia A; 4.4.1.3 Fanconi Anemia; 4.4.1.4 Engineered Blood Vessels; 4.4.2 iPSCs and Cardiovascular Diseases; 4.4.2.1 Long QT Syndrome; 4.4.3 iPSCs and Liver Diseases; 4.4.4 iPSCs and Spinal Cord Injury; 4.4.5 iPSCs and Diabetes and Related Complications; 4.4.6 iPSCs and Brain Diseases. 
520 |a This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of regenerative medicine since the day they were discovered. As stem cell research is complicated and making progress rapidly, it is important to have expertise in this field to share their views and perspectives. This book provides a wonderful platform for those who are interested in stem cells to learn from and communicate with experts. Particularly, it highlights the roles of stem cell based therapy for a variety of diseases. Furthermore, this book gives a detailed introduction to the great works related to stem cells in China. The readers could gain a profound knowledge of the state-of-art research done by scientists in the field of stem cells. Overall, this book will be a valuable reference resource for both experienced investigators pursuing stem cell research as well as those are just entering into this field. Dr. Robert Chunhua Zhao, a Cheung Kong Professor of Stem Cell Biology, is Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College (PUMC), Beijing, China. He is Director of the Center for Tissue Engineering, PUMC and Chief Scientist of the National Basic Research Program of China (ℓ́ℓ973 Programℓ́ℓ). He also serves as Regional Editor of Stem Cells and Development. 
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