Stem cells : basics and clinical translation / Robert Chunhua Zhao, editor.
This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of...
Saved in:
| Online Access: |
Full Text (via Springer) |
|---|---|
| Other Authors: | |
| Format: | eBook |
| Language: | English |
| Published: |
Shanghai : Dordrecht :
Shanghai Jiao Tong University Press ; Springer,
[2015]
|
| Series: | Translational medicine research.
|
| Subjects: |
Table of Contents:
- Series Foreword; Preface; Contents; Part I Basic Concepts of Stem Cells; 1 Primordial Germ Cells and Germ Line Stem Cells ; Abstract ; 1.1 The Origin and Fate of Germ Cells in Mammals; 1.1.1 PGC Specification in Mammals; 1.1.2 PGC Migration in Mammals; 1.1.3 PGC Development in Mammals; 1.2 Female Germ Line Stem Cells; 1.2.1 Introduction; 1.2.2 History of FGSC Research; 1.2.3 Current FGSC Research Progress; 1.2.3.1 FGSC Origin and Their Location; 1.2.3.2 FGSC Isolation and Culture; 1.2.3.3 FGSC Characterization; 1.2.3.4 FGSC Transplantation; 1.2.4 Applications of FGSCs.
- 1.3 Spermatogonial Stem Cells1.3.1 Introduction; 1.3.2 SSC Properties; 1.3.2.1 SSC Classification; 1.3.2.2 SSC Characteristics; 1.3.2.3 Reversibility and Heterogeneity; 1.3.3 SSC Niche; 1.3.4 Fate Decisions of SSCs; 1.4 Perspectives; References; 2 Human Amniotic Fluid-Derived and Amniotic Membrane-Derived Stem Cells ; Abstract ; 2.1 Amniotic Membrane and Amniotic Fluid; 2.2 Isolation and Culture; 2.2.1 AMSCs and AECs; 2.2.2 AFSCs; 2.3 Identification and Characterization; 2.4 Function Features; 2.4.1 Plasticity In Vivo; 2.4.2 Immunomodulation; 2.4.3 Epithelial-Mesenchymal Transition (EMT)
- 2.4.4 Angiogenic Potential2.4.5 Secretion Function; 2.5 The Potential Applications and Therapeutic Base; 2.5.1 Cardiac Regeneration; 2.5.2 Neuronal Regeneration; 2.5.3 Liver Disease; 2.5.4 Kidney Injury; 2.5.5 Skin Wounds and Burns; 2.5.6 Autoimmune Disease; 2.5.7 Premature Ovarian Failure; 2.5.8 Hematopoietic Supporting and Improvement; 2.5.9 Eye Injury; 2.5.10 Other Tissue Injury; 2.5.11 Potential Antitumor Therapeutic Strategies; 2.5.12 The Challenge of Clinical Translation; References; 3 Mesenchymal Stem Cells and Their Immunomodulatory Properties ; Abstract ; 3.1 Introduction.
- 3.2 Characteristics of MSC3.3 MSCs Exert Their Immunomodulation Function by Different Mechanisms; 3.3.1 The Interaction Between MSCs and T Cells; 3.3.2 The Interactions Between MSCs and Antigen-Presenting Cells; 3.3.3 The Interaction Between MSCs and B Cells; 3.3.4 Interaction Between MSCs and Natural Killer Cells; 3.3.5 MSCs Survive and Induce Immune Tolerance in the Host; 3.4 Applications of MSCs; 3.4.1 GVHD; 3.4.2 Organ Transplantation; 3.4.3 Chronic Inflammatory Autoimmune Diseases; 3.4.4 Conclusions and Future Directions; References.
- 4 Induced Pluripotent Stem Cell, a Rising Star in Regenerative Medicine Abstract ; 4.1 Introduction; 4.2 Characteristics of iPSCs; 4.3 Development of iPS Technology and Theory; 4.4 Potential Application of iPSCs in Disease Treatment; 4.4.1 iPSCs and Hematological Diseases; 4.4.1.1 Sickle Cell Anemia; 4.4.1.2 Hemophilia A; 4.4.1.3 Fanconi Anemia; 4.4.1.4 Engineered Blood Vessels; 4.4.2 iPSCs and Cardiovascular Diseases; 4.4.2.1 Long QT Syndrome; 4.4.3 iPSCs and Liver Diseases; 4.4.4 iPSCs and Spinal Cord Injury; 4.4.5 iPSCs and Diabetes and Related Complications; 4.4.6 iPSCs and Brain Diseases.