Vitamins and hormones. Volume 58 [electronic resource] : advances in research and applications / editor-in-chief, Gerald Litwack.
This volume may be divided into three groups of contributors. The first five chapters deal with polypeptides: GnRG receptor and apoptotic signaling; structure and function of the growth hormone-releasing hormone receptor; regulators of growth hormone signaling; and the EGF domain--requirements for b...
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Full Text (via ScienceDirect) |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
San Diego, Calif. ; London :
Academic Press,
©2000.
|
| Series: | Vitamins and hormones ;
v. 58. |
| Subjects: |
MARC
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| 245 | 0 | 0 | |a Vitamins and hormones. |n Volume 58 |h [electronic resource] : |b advances in research and applications / |c editor-in-chief, Gerald Litwack. |
| 260 | |a San Diego, Calif. ; |a London : |b Academic Press, |c ©2000. | ||
| 300 | |a 1 online resource (1 volume) : |b illustrations. | ||
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| 490 | 1 | |a Vitamins and hormones ; |v v. 58. | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Front Cover; Vitamins and Hormones; Copyright Page; Contents; Preface; Chapter 1. Protein Folding and Deficiencies Caused by Dominant-Negative Mutants of Hormones; I. Introduction; II. Functions of the Endoplasmic Reticulum Related to Protein Folding; III. Aspects of the Neuroendocrine Secretory Pathway; IV. Isolated Dominant-Negative Hormone Deficiency: Problems in the Secretory Pathway; V. Conclusions; References; Chapter 2. Structural Aspects of the G-Protein Receptor, Rhodopsin; I. Introduction; II. Seven Transmembrane Helical Hydrophobic Core of Rhodopsin. | |
| 505 | 8 | |a III. Structure of the Retinal and Its Binding Site in RhodopsinIV. Structure of Extramembranous Domains of Rhodopsin; V. Cytoplasmic Face of Rhodopsin; VI. Intradiskal Face of Rhodopsin; VII. Future Directions; References; Chapter 3. Molecular Modeling of Mammalian Cytochromes P450: Application to Study Enzyme Function; I. Introduction; II. Molecular Modeling Methods; III. Homology Models in Studies of P450 Function; IV. Perspectives and Conclusions; References; Chapter 4. Prostaglandin D Synthase: Structure and Function; I. Introduction. | |
| 505 | 8 | |a II. Pharmacologic Actions of Prostaglandin D2 and Its MetabolitesIII. Lipocalin-Type Prostaglandin D Synthase (ß-Trace); IV. Hematopoietic Prostaglandin D Synthase; V. Future Studies; References; Chapter 5. Steroid Dehydrogenase Structures, Mechanism of Action, and Disease; I. Introduction; II. 3a,20ß -Hydroxysteroid Dehydrogenase; III. Aldosterone, Cortisol, Licorice, and Hypertension; IV. 17ß -Hydroxysteroid Dehydrogenase, Inhibitors, and Cancer; V. Protein Sequence and Three-Dimensional Conformation; VI. Conclusions; References; Chapter 6. Structure-Based Inhibitor Design; I. Introduction. | |
| 505 | 8 | |a II. Target Selection, Cloning, and Determination of 3-D StructuresIII. Crystallographic Water Molecules; IV. Computational Approaches to Lead Compound Discovery; V. Estimating the Theoretical Limits for Reversible Inhibitor Binding; VI. Connectivity, Flexibility, and Conformational Entropy; VII. Using Enzyme Structures in Dealing with Resistance Mutations; VIII. Conclusions; References; Chapter 7. Protein Folding Using Contact Maps; I. Introduction; II. Structure Representation; III. The Reconstruction Procedure; IV. Dynamics in Contact Map Space; V. Approximation for Free Energy; VI. Results. | |
| 505 | 8 | |a VII. ConclusionsReferences; Chapter 8. HIV Protease: Enzyme Function and Drug Resistance; I. Introduction; II. HIV PR Is a Member of the Aspartic Proteinase Family; III. HIV PR Structure; IV. Mechanism of the Substrate Cleavage and Protonation State of the Catalytic Aspartates; V. Substrate Specificity; VI. Assay Methods; VII. pH Optima; VIII. Dimer Stability; IX. Thermodynamic Characteristics of Inhibitor Binding; X. Inhibitors of HIV PR; XI. Introduction to Resistance to HIV PR Inhibitors; XII. Active Site Mutations; XIII. Nonactive Site Mutations; XIV. Cleavage Site Mutants. | |
| 520 | |a This volume may be divided into three groups of contributors. The first five chapters deal with polypeptides: GnRG receptor and apoptotic signaling; structure and function of the growth hormone-releasing hormone receptor; regulators of growth hormone signaling; and the EGF domain--requirements for binding the receptors to the Erb-B family enkephalin-cell interaction. The next three manuscripts cover the steroid receptor gene family emphasizing structure, expression and action: studies on structure activity relationships of retinoic acid receptor ligands by means of molecular modelling; glucocorticoid-regulated gene expression during cutaneous wound repair; and dioxin action, hormone action and endocrine homeostasis. The final three chapters cover leptin receptors and vitamins: control of food intake via leptin receptors in the hypothalamus; Vitamin E and immunity; and Transcobalamin II and its cell surface receptor. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Steroid hormones. |0 http://id.loc.gov/authorities/subjects/sh85128053. | |
| 650 | 0 | |a Peptide hormones. |0 http://id.loc.gov/authorities/subjects/sh85099689. | |
| 650 | 7 | |a Peptide hormones. |2 fast |0 (OCoLC)fst01057558. | |
| 650 | 7 | |a Steroid hormones. |2 fast |0 (OCoLC)fst01133262. | |
| 700 | 1 | |a Litwack, Gerald. |0 http://id.loc.gov/authorities/names/n79096849 |1 http://isni.org/isni/0000000108959820. | |
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