Therapeutic applications of quadruplex nucleic acids [electronic resource] / Stephen Neidle.
New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no...
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Full Text (via ScienceDirect) |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
London ; Waltham, MA :
Elsevier/Academic Press,
2012.
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| Edition: | 1st ed. |
| Subjects: |
MARC
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| 245 | 1 | 0 | |a Therapeutic applications of quadruplex nucleic acids |h [electronic resource] / |c Stephen Neidle. |
| 250 | |a 1st ed. | ||
| 260 | |a London ; |a Waltham, MA : |b Elsevier/Academic Press, |c 2012. | ||
| 300 | |a 1 online resource (xii, 196 pages) : |b illustrations | ||
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| 520 | |a New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. This timely publication is the first to offer practical application and direct strategies to meet the needs of emerging research. | ||
| 505 | 0 | |a Intro -- history and milestones -- Fundamentals of DNA and RNA quadruplex structure and stability -- Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance -- Genomic DNA and RNA quadruplexes -- involvement in gene expression and potential as therapeutic agents -- Quadruplex targets and human disease -- applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit -- Quadruplex ligands -- chemistry and design -- selectivity and assays -- Quadruplex ligands -- basic biology and assays indirect and direct -- Quadruplex ligands -- pharmacology and druggability, ligands in clinical trial and pre-clinical trial development -- Synthetic quadruplexes and drugs -- therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding -- Future directions and conclusions. | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Quadruplex nucleic acids |x Therapeutic use. | |
| 776 | 0 | 8 | |i Print version: |a Neidle, Stephen. |t Therapeutic applications of quadruplex nucleic acids. |b 1st ed. |d London ; Waltham, MA : Elsevier/Academic Press, 2012 |z 9780123751386 |w (DLC) 2011293620 |w (OCoLC)759821822 |
| 856 | 4 | 0 | |u https://colorado.idm.oclc.org/login?url=https://www.sciencedirect.com/science/book/9780123751386 |z Full Text (via ScienceDirect) |
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