RNA turnover in eukaryotes [electronic resource] : nucleases, pathways and analysis of mRNA decay / edited by Lynne E. Maquat, Megerditch Kiledjian.
Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a...
Saved in:
| Online Access: |
Full Text (via ScienceDirect) |
|---|---|
| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
San Diego, Calif. ; London :
Academic,
©2008.
|
| Series: | Methods in enzymology ;
v. 448. |
| Subjects: |
| Summary: | Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors, and mRNA instability elements, responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation. The control of biological processes, such as cellular growth and differentiation, is dependent on how the genetic material within a cell is expressed. The cellular physiology of mRNA-including mRNA processing, transport, localization, and turnover-is central to the process of gene expression. Covers the nonsense-mediated mRNA decay (NMD) or mRNA surveillance pathway. Expert researchers introduce the most advanced technologies and techniques to identify mRNA processing, transport, localization and turnover which are central to the process of gene expression. Offers step-by-step lab instructions including necessary equipment and reagents. |
|---|---|
| Physical Description: | 1 online resource (xlviii, 607 pages, 5 unnumbered pages of plates) : illustrations (some color) |
| Bibliography: | Includes bibliographical references and indexes. |
| ISBN: | 9780080922072 0080922074 9780123743787 0123743788 |
| ISSN: | 0076-6879 ; |
| Source of Description, Etc. Note: | Source of description: Print version record. |