Biochemistry of oxidative stress : physiopathology and clinical aspects / Ricardo Jorge Gelpi, Alberto Boveris, Juan José Poderoso, editors.
The strongest point of this book titled “Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects”, is that the academic and scientific background of the authors/editors guarantee the authorship of a book comprising all aspects of oxidative stress, ranging from very molecular aspects,...
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| Online Access: |
Full Text (via Springer) |
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| Other Authors: | , , |
| Format: | eBook |
| Language: | English |
| Published: |
Cham, Switzerland :
Springer,
2016.
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| Series: | Advances in biochemistry in health and disease ;
v. 16. |
| Subjects: |
MARC
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| 245 | 0 | 0 | |a Biochemistry of oxidative stress : |b physiopathology and clinical aspects / |c Ricardo Jorge Gelpi, Alberto Boveris, Juan José Poderoso, editors. |
| 264 | 1 | |a Cham, Switzerland : |b Springer, |c 2016. | |
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| 490 | 1 | |a Advances in biochemistry in health and disease ; |v 16. | |
| 505 | 0 | |a Preface; Contents; Part I: General Aspects; Chapter 1: The Concept of Oxidative Stress After 30 Years; 1 Introduction; 2 Concept of "Oxidative Stress"; 3 The Redox Code; 4 Specific Forms of Oxidative Stress; 5 Role of Hydrogen Peroxide in Oxidative Stress and Redox Signaling; 6 Molecular Redox Switches; 7 Redox Medicine; 8 Cautionary Words; 9 Conclusions; References; Chapter 2: The Evolution of the Earth and Its Atmosphere; 1 Evolution of the Earth: Geologic Timeline; 1.1 Precambrian; 1.2 Paleozoic; 1.3 Mesozoic; 1.4 Cenozoic; 1.5 Quaternary; 2 The Origin of Mitochondria. | |
| 505 | 8 | |a 2.1 How Did the Mitochondrial Endo Symbiogenesis Occurred?3 Geological History of Oxygen; 3.1 Effects on Life; 4 Conclusion; References; Chapter 3: Mitochondria Are the Main Cellular Source of O2−, H2O2 and Oxidative Stress; 1 Introduction. The Partial Reduction of Oxygen and the Reactive Oxygen Species; 2 The Mitochondrial Production of O2− and H2O2; 3 Mitochondrial Function in Cell Physiology; 4 Steady States and Half Lives of Reactive Oxygen Species; 5 Oxidative Stress; 6 Physiology of the Products of the Partial Reduction of Oxygen. | |
| 505 | 8 | |a 7 Experimental Determination of Oxidative Stress in Cells and Tissues8 Aging; 9 Conclusions; References; Chapter 4: Biochemistry and Physiology of Heart Mitochondrial Nitric Oxide Synthase; 1 Introduction; 2 Nitric Oxide Regulates Mitochondrial Respiration and Superoxide Anion and Hydrogen Peroxide Productions; 3 Other Effects of NO and NO-Derived Species on Mitochondrial Functions; 4 Heart mtNOS Activity and Identity; 5 Regulation of Heart Mitochondrial NOS; 6 Conclusions; References; Chapter 5: Biochemistry of Nitric Oxide and Peroxynitrite: Sources, Targets and Biological Implications. | |
| 505 | 8 | |a 1 Introduction2 Nitric Oxide: Sources and Destination of an Ubiquitous Reactive Nitrogen Species; 2.1 Biological Formation of NO; 2.2 Fates of NO; 2.3 Autoxidation Reactions; 2.4 Reactions with Radical Species; 2.5 Reaction with Metal Centers; 3 Peroxynitrite: A Potential Harm for Multiple Biomolecules; 3.1 Biological Formation of ONOO−; 3.2 Fates of ONOO−; 3.3 Carbon Dioxide; 3.4 Thiols; 3.5 Metal Centers; 3.6 Tyrosine Residues; 3.7 DNA; 3.8 Lipids; 4 Physiology and Pathophysiology of NO and Peroxynitrite-Derived Oxidants; 4.1 Peroxynitrite and Mitochondrial Dysfunction. | |
| 505 | 8 | |a 4.2 Apoptosis and Necrosis4.3 Peroxynitrite, Inflammation and Immune Responses; 4.4 Reactive Nitrogen Species in the Development of Cardiovascular Disease; 4.5 Neurodegenerative Diseases and Nitroxidative Damage; 4.6 Sepsis; 4.7 Cancer; 5 Pharmacology Directed to Prevent Nitroxidative Damage; 5.1 Inhibitors of ONOO− Formation ; 5.2 Direct Antioxidants; 5.3 Catalytic Antioxidants; 5.4 Antioxidant Inducers; 6 Conclusions; References; Chapter 6: Nitro-arachidonic Acid: Downstream Signaling and Therapeutics; 1 Introduction; 2 Mechanisms of Arachidonic Acid Nitration. | |
| 520 | |a The strongest point of this book titled “Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects”, is that the academic and scientific background of the authors/editors guarantee the authorship of a book comprising all aspects of oxidative stress, ranging from very molecular aspects, to clinical application, including the antioxidant therapy. Of particular importance is the fact that the aforementioned aspects are described in the book in a general section and in three different and important pathologies, such as cardiovascular diseases, neurodegenerative diseases, and cancer. The importance of these pathologies lays in the fact that, taken separately or together, they represent by far the leading cause of death in the world. Finally, all the chapters have been written by highly recognized authorities in the field of their investigations. At least to our knowledge, this is the first book with this characteristics in the field of oxidative stress. | ||
| 650 | 0 | |a Oxidative stress. |0 http://id.loc.gov/authorities/subjects/sh2003008365. | |
| 650 | 7 | |a Oxidative stress. |2 fast |0 (OCoLC)fst01049566. | |
| 700 | 1 | |a Gelpi, Ricardo J., |e editor. |0 http://id.loc.gov/authorities/names/n2017183961 |1 http://isni.org/isni/0000000464751532. | |
| 700 | 1 | |a Boveris, Alberto, |e editor. |0 http://id.loc.gov/authorities/names/n2006181351. | |
| 700 | 1 | |a Poderoso, Juan José, |e editor. |0 http://id.loc.gov/authorities/names/n2017183963 |1 http://isni.org/isni/0000000464751567. | |
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