Biochemistry of oxidative stress : physiopathology and clinical aspects / Ricardo Jorge Gelpi, Alberto Boveris, Juan José Poderoso, editors.
The strongest point of this book titled “Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects”, is that the academic and scientific background of the authors/editors guarantee the authorship of a book comprising all aspects of oxidative stress, ranging from very molecular aspects,...
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| Online Access: |
Full Text (via Springer) |
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| Other Authors: | , , |
| Format: | eBook |
| Language: | English |
| Published: |
Cham, Switzerland :
Springer,
2016.
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| Series: | Advances in biochemistry in health and disease ;
v. 16. |
| Subjects: |
Table of Contents:
- Preface; Contents; Part I: General Aspects; Chapter 1: The Concept of Oxidative Stress After 30 Years; 1 Introduction; 2 Concept of "Oxidative Stress"; 3 The Redox Code; 4 Specific Forms of Oxidative Stress; 5 Role of Hydrogen Peroxide in Oxidative Stress and Redox Signaling; 6 Molecular Redox Switches; 7 Redox Medicine; 8 Cautionary Words; 9 Conclusions; References; Chapter 2: The Evolution of the Earth and Its Atmosphere; 1 Evolution of the Earth: Geologic Timeline; 1.1 Precambrian; 1.2 Paleozoic; 1.3 Mesozoic; 1.4 Cenozoic; 1.5 Quaternary; 2 The Origin of Mitochondria.
- 2.1 How Did the Mitochondrial Endo Symbiogenesis Occurred?3 Geological History of Oxygen; 3.1 Effects on Life; 4 Conclusion; References; Chapter 3: Mitochondria Are the Main Cellular Source of O2−, H2O2 and Oxidative Stress; 1 Introduction. The Partial Reduction of Oxygen and the Reactive Oxygen Species; 2 The Mitochondrial Production of O2− and H2O2; 3 Mitochondrial Function in Cell Physiology; 4 Steady States and Half Lives of Reactive Oxygen Species; 5 Oxidative Stress; 6 Physiology of the Products of the Partial Reduction of Oxygen.
- 7 Experimental Determination of Oxidative Stress in Cells and Tissues8 Aging; 9 Conclusions; References; Chapter 4: Biochemistry and Physiology of Heart Mitochondrial Nitric Oxide Synthase; 1 Introduction; 2 Nitric Oxide Regulates Mitochondrial Respiration and Superoxide Anion and Hydrogen Peroxide Productions; 3 Other Effects of NO and NO-Derived Species on Mitochondrial Functions; 4 Heart mtNOS Activity and Identity; 5 Regulation of Heart Mitochondrial NOS; 6 Conclusions; References; Chapter 5: Biochemistry of Nitric Oxide and Peroxynitrite: Sources, Targets and Biological Implications.
- 1 Introduction2 Nitric Oxide: Sources and Destination of an Ubiquitous Reactive Nitrogen Species; 2.1 Biological Formation of NO; 2.2 Fates of NO; 2.3 Autoxidation Reactions; 2.4 Reactions with Radical Species; 2.5 Reaction with Metal Centers; 3 Peroxynitrite: A Potential Harm for Multiple Biomolecules; 3.1 Biological Formation of ONOO−; 3.2 Fates of ONOO−; 3.3 Carbon Dioxide; 3.4 Thiols; 3.5 Metal Centers; 3.6 Tyrosine Residues; 3.7 DNA; 3.8 Lipids; 4 Physiology and Pathophysiology of NO and Peroxynitrite-Derived Oxidants; 4.1 Peroxynitrite and Mitochondrial Dysfunction.
- 4.2 Apoptosis and Necrosis4.3 Peroxynitrite, Inflammation and Immune Responses; 4.4 Reactive Nitrogen Species in the Development of Cardiovascular Disease; 4.5 Neurodegenerative Diseases and Nitroxidative Damage; 4.6 Sepsis; 4.7 Cancer; 5 Pharmacology Directed to Prevent Nitroxidative Damage; 5.1 Inhibitors of ONOO− Formation ; 5.2 Direct Antioxidants; 5.3 Catalytic Antioxidants; 5.4 Antioxidant Inducers; 6 Conclusions; References; Chapter 6: Nitro-arachidonic Acid: Downstream Signaling and Therapeutics; 1 Introduction; 2 Mechanisms of Arachidonic Acid Nitration.