Computational modelling of the human islet amyloid polypeptide / by Katrine Kirkeby Skeby.
This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own...
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Full Text (via Springer) |
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| Format: | eBook |
| Language: | English |
| Published: |
Switzerland :
Springer,
2016.
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| Series: | Springer theses.
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| Subjects: |
MARC
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| 245 | 1 | 0 | |a Computational modelling of the human islet amyloid polypeptide / |c by Katrine Kirkeby Skeby. |
| 264 | 1 | |a Switzerland : |b Springer, |c 2016. | |
| 300 | |a 1 online resource (xvi, 118 pages) : |b illustrations (some color) | ||
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| 500 | |a "Doctoral thesis accepted by the Aarhus University, Aarhus C, Denmark." | ||
| 504 | |a Includes bibliographical references. | ||
| 505 | 0 | |a Amyloid and Amyloid Fibrils -- Computational Theory -- Imaging Agent Binding to Amyloid Protofibrils -- Determining the Aggregation Prone Structure of hiAPP -- Effect of Terminal Capping on Aggregation of Peptide Fragments -- Coarse Grained Study of Amyloid Protofibril Aggregation -- Conclusion and Perspectives. | |
| 520 | |a This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own work. Amyloid proteins are highly complex, and this research provides unparalleled insights, especially with regard to the origin of cytotoxicity and to developing technologies for early detection, revealing in detail the molecular mechanisms behind hIAPP behavior. Several studies within the thesis answer difficult questions which promote future research into the properties of amyloid proteins. | ||
| 588 | 0 | |a Online resource; title from PDF title page (SpringerLink, viewed June 7, 2016) | |
| 650 | 0 | |a Amyloid |x Simulation methods. | |
| 650 | 0 | |a Proteins |x Metabolism |x Disorders |x Simulation methods. | |
| 650 | 7 | |a Bioorganic chemistry. |2 fast |0 (OCoLC)fst00832648. | |
| 650 | 7 | |a Cheminformatics. |2 fast |0 (OCoLC)fst00853337. | |
| 650 | 7 | |a Chemistry. |2 fast |0 (OCoLC)fst00853344. | |
| 650 | 7 | |a Pharmaceutical chemistry. |2 fast |0 (OCoLC)fst01060115. | |
| 776 | 0 | 8 | |i Print version: |a Skeby, Katrine Kirkeby. |t Computational modelling of the human islet amyloid polypeptide. |d Switzerland : Springer, c2016 |h xvi, 118 pages |k Springer theses. |x 2190-5061 |z 9783319200392 |w (DLC) 2016939051. |
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