Crystal structures of the components of the <i>Staphylococcus aureus</i> leukotoxin ED [electronic resource]
Luke; Lukd; Leukotoxin; Poreforming Toxins; Staphylococcus Aureus.
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| Online Access: |
Online Access (via OSTI) |
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| Corporate Author: | |
| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Washington, D.C. : Oak Ridge, Tenn. :
United States. Department of Energy. ; distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
2016.
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| Subjects: |
| Summary: | Luke; Lukd; Leukotoxin; Poreforming Toxins; Staphylococcus Aureus. |
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| Abstract: | Staphylococcal leukotoxins are a family of β-barrel, bicomponent, pore-forming toxins with membrane-damaging functions. These bacterial exotoxins share sequence and structural homology and target several host-cell types. Leukotoxin ED (LukED) is one of these bicomponent pore-forming toxins that<italic>Staphylococcus aureus</italic>produces in order to suppress the ability of the host to contain the infection. The recent delineation of the important role that LukED plays in<italic>S. aureus</italic>pathogenesis and the identification of its protein receptors, combined with its presence in<italic>S. aureus</italic>methicillin-resistant epidemic strains, establish this leukocidin as a possible target for the development of novel therapeutics. Here, the crystal structures of the water-soluble LukE and LukD components of LukED have been determined. Lastly, the two structures illustrate the tertiary-structural variability with respect to the other leukotoxins while retaining the conservation of the residues involved in the interaction of the protomers in the bipartite leukotoxin in the pore complex. |
| Item Description: | Published through SciTech Connect. 01/01/2016. Acta Crystallographica. Section D. Structural Biology 72 1 ISSN 2059-7983; ACSDAD AM. S. Nocadello; G. Minasov; L. Shuvalova; I. Dubrovska; E. Sabini; F. Bagnoli; G. Grandi; W. F. Anderson. |
| Physical Description: | p. 113-120 : digital, PDF file. |