Epigenetics of infectious diseases [electronic resource] / Walter Doerfler, Josep Casadesús, editors.
The present volume of Epigenetics and Human Health is devoted to the patho-epigenetics of viral and microbial infections, an exiting new field of disease-related epigenetic research. As recognized during the past years, epigenetic reprogramming of pathogen and host genome functions - the latter freq...
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| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
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Cham :
Springer,
2017.
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| Series: | Epigenetics and human health.
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Table of Contents:
- Preface; Contents; Chapter 1: DNA Methylation of Human Papillomavirus Genomes During Infection and Cancer Progression; 1.1 Introduction; 1.2 History of Papillomavirus Methylation Research; 1.3 Methylation of HPV DNA During the Normal Life Cycle; 1.3.1 In Summary; 1.4 Regulatory Effects of DNA Methylation via CpG Dinucleotides in E2 Binding Sites; 1.5 Effects of Papillomaviruses on the Cellular Epigenome; 1.6 Differential Methylation of HPV Genomes in Malignant Lesions; 1.7 HPV Epigenomes and Cellular Epigenomic Properties of HPV Infected Cells as Cancer Biomarkers; References.
- Chapter 2: Epigenetic Regulation of Gammaherpesviruses: A Focus on Kaposiś Sarcoma-Associated Herpesvirus (KSHV/HHV-8)2.1 Introduction; 2.1.1 Genome Organization and Circularization; 2.1.2 Gene Expression During Latency; 2.1.3 Gene Expression During Lytic Phase; 2.2 Histone Modifications; 2.2.1 Histone Modifications During Gammaherpesvirus Latency; 2.2.2 Histone Modifications During Lytic Reactivation; 2.2.3 Intra- and Inter-locus Epigenetic Heterogeneity in KSHV Episomes; 2.3 DNA Methylation; 2.4 Chromatin Organization by CTCF and the Cohesin Complex.
- 2.5 Noncoding RNAs and Epigenetic Control2.6 Conclusions; References; Chapter 3: Discoveries in Molecular Genetics with the Adenovirus 12 System: Integration of Viral DNA and Epigenetic Consequenc ... ; 3.1 Background on Interest in DNA Methylation and Epigenetic Effects; 3.1.1 Introduction to the Adenovirus System; 3.1.1.1 Ad12-Syrian Hamster Cells: The Abortive System; 3.1.2 Foreign DNA in the Environment; 3.1.3 Biology of Ad12-Induced Hamster Tumors; 3.1.4 Characteristics of Chromosomally Integrated Adenovirus DNA.
- 3.1.5 The Consequences of Inserting Foreign DNA into Established Mammalian Genomes3.1.5.1 Hypermethylation of Integrated Ad12 DNA, the Transgenome; 3.1.5.2 Promoter CpG Methylation and Promoter Silencing; 3.1.5.3 Foreign DNA Integration into Mammalian Genomes Leads to Alterations in Methylation and Transcription Patterns; Genome-Wide Increases in DNA Methylation in Ad12-Transformed Cells-Stability of Changes Even After the Loss of All Viral Genom ... ; Alterations of Cellular DNA Methylation and Transcription Patterns Are Also Elicited in Bacteriophage Lambda or Bacterial Plas .
- Alterations of CpG Methylation Patterns Way Upstream of the FMR1 Boundary in Human Cells Immortalized by Epstein-Barr Virus (E ... A Model System to Study the Epigenomic Destabilization in Human Cells Transgenomic for a 5.6 kbp Bacterial Plasmid; 3.1.6 Résumé; References; Chapter 4: Epigenetic Consequences of Epstein-Barr Virus Infection; 4.1 Epigenetic Regulation of the EBV Life Cycle; 4.1.1 EBV Life Cycle; 4.1.2 Epigenetic Control of Viral Promoter Usage; 4.1.3 Epigenetic Regulation of Lytic Reactivation; 4.2 Viral Protein Interactions with the Host Epigenetic Machinery; 4.2.1 EBNA1.