Neurobiology of Epilepsy [electronic resource]
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| Online Access: |
Full Text (via ProQuest) |
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| Main Author: | |
| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
San Diego :
Elsevier Science,
2016.
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| Series: | Progress in brain research.
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| Subjects: |
Table of Contents:
- Front Cover; Neurobiology of Epilepsy: From Genes to Networks; Copyright; Contributors; Contents; Preface; Chapter 1: Multimodal investigation of epileptic networks: The case of insular cortex epilepsy; 1. Epilepsy as a Systems Disease; 2. Investigating the Epileptic Networks: Clinical Practice; 2.1. Presurgical Investigation Techniques; 2.1.1. icEEG; 2.1.2. EEG; 2.1.3. MEG; 2.1.4. MRI; 2.1.5. PET; 2.1.6. SPECT; 2.2. Illustrative Case; 3. Investigating the Epileptic Networks: Perspectives; 3.1. Advanced Localization Techniques; 3.1.1. EEG/MEG fusion; 3.1.2. Combined EEG and fMRI.
- 3.1.3. Quantified icEEG3.1.4. Neuroimaging brain networks; 3.1.5. EEG/MEG connectivity; 3.1.6. fMRI connectivity; 3.1.7. Structural connectivity; 3.1.8. icEEG connectivity; 3.1.8.1. Static network properties; 3.1.8.2. Network dynamics: Synchrony; 3.1.8.3. Network dynamics: Directionality; 3.1.8.4. Network dynamics: The case of ICE; 4. Conclusion; References; Chapter 2: Genetic investigations of the epileptic encephalopathies: Recent advances; 1. Background; 2. CNVs in Epilepsy; 3. Massively Parallel Sequencing in Epilepsy; 4. Genetic Heterogeneity in EE; 5. Expanding the Phenotypic Spectrum.
- 6. Next Steps in Mutation Discovery7. Precision Diagnostics for Precision Therapies; 8. Conclusions and Future Directions; Acknowledgments; References; Chapter 3: mTOR signaling pathway genes in focal epilepsies; 1. GATOR1 Complex Acts as a Repressor of the mTORC1 Signaling Pathway; 2. DEPDC5 Mutations in Focal Epilepsy Syndromes; 3. DEPDC5 Mutations in Malformations of Cortical Development; 3.1. Mutational Spectrum of DEPDC5 Gene; 3.2. Mutational Spectrum of NPRL2 and NPRL3 Genes; 4. Clinical Features of Families with GATOR1 Complex Gene Mutations.
- 5. The Singularities of GATOR1-Related Epilepsies6. How Are GATOR1 Mutations Related to Defects in the mTORC1 Pathway?; 6.1. In Vitro Functional Assays; 6.2. In Patient Resected Brain Tissue; 7. Animal Models of GATOR1 Deficiency; 8. Brain Somatic Mutations in MTOR; 9. Conclusions; Acknowledgments; References; Chapter 4: Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy; 1. Introduction; 2. Cortical Interneuron Diversity; 3. Cell-Type Specification; 4. Migration; 4.1. Transcription Factors Regulating the Migration of INs.
- 4.2. Chemotaxis of INs Toward the Cortical Plate4.3. Neuronal Locomotion, Neurite Extension, Neurite Branching, and Nucleokinesis; 5. Maturation and Cell Survival; 5.1. Maturation of PV INs: Focus on the PNN; 5.2. Cell Survival; 6. Neuronal Excitability; 6.1. Voltage-Gated Sodium Channels; 6.2. Voltage-Gated Potassium Channels; 7. Synaptic Connectivity; 7.1. Synaptogenesis: GABAergic Synapse Formation and Maturation; 7.2. Synaptic Function; 7.3. Excitatory and Inhibitory Innervation of PV INs; 8. Functional Networks; 9. Perspectives; Acknowledgments; References.