Computational modeling of drugs against Alzheimer's disease / edited by Kunal Roy.
"This volume describes different computational methods encompassing ligand-based approaches (QSAR, pharmcophore), structure-based approaches (homology modeling, docking, molecular dynamics simulation), and combined approaches (virtual screening) with applications in anti-Alzheimer drug design....
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Full Text (via Springer) |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
New York, NY :
Humana Press imprint is published by Springer Nature,
[2018]
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| Series: | Neuromethods ;
132. Springer protocols (Series) |
| Subjects: |
Table of Contents:
- An introduction to the disease. Alzheimer's disease therapy: present and future molecules / Awanish Kumar, Ashwini Kumar
- Computational modeling methods for anti-Alzheimer agents. Recent advances in computational approaches for designing potential anti-Alzheimer's agents / Sergi Gómez-Ganau, Jesús Vicente de Julián-Ortiz, Rafael Gozalbes
- Computer-aided drug design approaches to study key therapeutic targets in Alzheimer's disease / Agostinho Lemos, Rita Melo, Irina S. Moreira, M. Natália D.S. Cordeiro
- Virtual screening in the search of new and potent anti-Alzheimer agents / Livia Basile
- Molecular field topology analysis (MFTA) in the design of neuroprotective compounds / Eugene V. Radchenko, Vladimir A. Palyulin, Nikolay S. Zefirov
- Modeling of ligands acting against specific anti-Alzheimer drug targets. Galantamine derivatives as acetylcholinesterase inhibitors: docking, design, synthesis, and inhibitory activity / Irini Doytchinova, Mariyana Atanasova, Georgi Stavrakov, Irena Philipova, Dimitrina Zheleva-Dimitrova
- Modeling of BACE-1 inhibitors as anti-Alzheimer's agents / Odailson Santos Paz, Thamires Quadros Froes, Franco Henrique Leite, Marcelo Santos Castilho
- Design of anti-Alzheimer's disease agents focusing on a specific interaction with target biomolecules / Yoshio Hamada, Kenji Usui
- Molecular docking and molecular dynamics simulation to evaluate compounds that avoid the amyloid beta aggregation / Maricarmen Hernández Rodríguez, Leticia Guadalupe Fragoso Morales, José Correa Basurto, Martha Cecilia Rosales Hernández
- In silico strategies to design small molecules to study beta-amyloid aggregation / Praveen P.N. Rao, Deguo Du
- Computational approaches to understand cleavage mechanism of amyloid beta (A[beta]) peptide / Kailas Dashrath Sonawane, Maruti Jayaram Dhanavade
- Computational modeling of gamma-secretase inhibitors as anti-Alzheimer agents / Prabu Manoharan, Nanda Ghoshal
- Molecular modeling of tau proline-directed protein kinase (PDPK) inhibitors / Carlos Navarro-Retamal, Julio Caballero
- Computational modelling of kinase inhibitors as anti-Alzheimer agents / Mange Ram Yadav, Mahesh A. Barmade, Rupesh V. Chikhale, Prashant R. Murumkar
- Computational modeling of drugs for Alzheimer's disease: design of serotonin 5-HT6 antagonists / Ádám A. Kelemen, Stefan Mordalski, Andrzej J. Bojarski, György M. Keserű
- Computational modeling of diagnostic imaging agents for Alzheimer's disease: molecular imaging agents for the in vivo detection of amyloid plaques in Alzheimer's disease / Dionysia Papagiannopoulou, Dimitra Hadjipavlou-Litina
- Special topics. Computational approaches for therapeutic application of natural products in Alzheimer's disease / Manika Awasthi, Swati Singh, Sameeksha Tiwari, Veda P. Pandey, Upendra N. Dwivedi
- In silico studies applied to natural products with potential activity against Alzheimer's disease / Luciana Scotti, Marcus T. Scotti
- Computational modeling of multi-target-directed inhibitors against Alzheimer's disease / Akhil Kumar, Ashok Sharma
- Neuropharmacology in flux: molecular modeling tools for understanding protein conformational shifts in Alzheimer's disease and related disorders / Gerald H. Lushington, Frances E.S. Parker, Thomas H.W. Lushington, Nora M. Wallace
- Computational nanotechnology: a tool for screening therapeutic nanomaterials against Alzheimer's disease / R. Navanietha Krishnaraj, Dipayan Samanta, Rajesh K. Sani.