Diversity of selenium functions in health and disease / edited by Regina Brigelius-Flohé, Helmut Sies.
Named after Selene, Greek goddess of the moon, selenium (Se) has moved has moved from being thought of as a toxicant to being considered an essential nutrient with the potential to reduce cancer risk in the span of seven decades. Diversity of Selenium Functions in Health and Disease focuses on curre...
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Full Text (via Taylor & Francis) |
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| Other Authors: | , |
| Format: | eBook |
| Language: | English |
| Published: |
Boca Raton :
CRC Press, Taylor & Francis Group,
[2016]
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| Series: | Oxidative stress and disease ;
38. |
| Subjects: |
MARC
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| 245 | 0 | 0 | |a Diversity of selenium functions in health and disease / |c edited by Regina Brigelius-Flohé, Helmut Sies. |
| 264 | 1 | |a Boca Raton : |b CRC Press, Taylor & Francis Group, |c [2016] | |
| 264 | 4 | |c ©2016 | |
| 300 | |a 1 online resource (xxix, 400 pages) : |b illustrations. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a volume |b nc |2 rdacarrier | ||
| 490 | 1 | |a Oxidative stress and disease ; |v 38 | |
| 520 | |a Named after Selene, Greek goddess of the moon, selenium (Se) has moved has moved from being thought of as a toxicant to being considered an essential nutrient with the potential to reduce cancer risk in the span of seven decades. Diversity of Selenium Functions in Health and Disease focuses on current knowledge of aspects of Se research relevant to its medical use, and particularly to chemoprevention of cancer. It covers how Se is integrated into selenoproteins, selenium compounds with individual functions and dual functions, and unexpected links to Se such as with diabetes. The text ends with a discussion of polymorphisms and mutations in genes of selenoproteins. The chapters elucidate why studies undertaken to prevent diseases with selenium ended with disappointing outcomes and often with the opposite result, i.e. disease promotion. They show that benefit, failure, or side effects depend on: The chemical form and dose of selenium The selenium status of the individual ingesting selenium The capacity of selenium form to serve as a source for selenoprotein biosynthesis The function of selenoproteins reacting to a change in the selenium status The stage of the disease (mainly cancer) at the time point of intervention The genetic background of individuals to be treated Bringing together the accumulated evidence regarding selenium biochemistry, the book covers aspects not found in available general monographs. The narrow focus on medical uses of Se helps resolve the present confusion about potential benefits and hazards of selenium in human health. The book gives you a solid scientific basis for optimum use of selenium in preventing or treating human diseases and answering the questions: Why is selenium essential? How much is required? What are the health consequences of low selenium and can selenium reduce cancer risk? | ||
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Who can benefit from selenium? / Gerald F. Combs, Jr. -- Selenium metabolism / Yasumitsu Ogra -- The molecular regulation of selenocysteine incorporation into proteins in eukaryotes / Aditi Dubey and Paul R. Copeland -- Selenocysteine tRNA: the central component of selenoprotein biosynthesis / Bradley A. Carlson, Ryuta Tobe, Petra A. Tsuji, Min-Hyuk Yoo, Lionel Feigenbaum, Lino Tessarollo, Byeong J. Lee, Ulrich Schweizer, Vadim N. Gladyshev, and Dolph L. Hatfield -- Redox cycling and the toxicity of selenium compounds: a historical view / Julian E. Spallholz -- Selenite in cancer therapy / Sougat Misra, Marita Wallenberg, Ola Brodin, and Mikael Björnstedt -- Forms of selenium in cancer prevention / Karam El-Bayoumy, Raghu Sinha, and John P. Richie, Jr. -- Thioredoxin reductase 1 / Bradley A. Carlson -- Glutathione Peroxidase 2 / Anna P. Kipp and Mike F. Müller -- The 15-kDa selenoprotein (SEP15) / Petra A. Tsuji and Cindy D. Davis -- Multifaceted and intriguing effects of selenium and selenoproteins on glucose metabolism and diabetes / Ji-Chang Zhou, Holger Steinbrenner, Margaret P. Rayman, and Xin Gen Lei -- Selenoproteins and the metabolic syndrome / Lucia A. Seale, Ann Marie Zavacki, and Marla J. Berry -- Thioredoxin reductase: a coordinator in metabolic activities / Sofi Eriksson and Edward E. Schmidt -- Selenium mediates a switch in macrophage polarization / K. Sandeep Prabhu, Avinash K. Kudva, and Shakira M. Nelson -- Genetic polymorphisms in selenoprotein genes, functionality and disease risk / Catherine Méplan, Janaina Lombello Santos Donadio, and John Hesketh -- Mutations in SECISBP2 / Erik Schoenmakers, Carla Moran, Nadia Schoenmakers, and Krishna Chatterjee. | |
| 588 | 0 | |a Print version record. | |
| 546 | |a English. | ||
| 650 | 0 | |a Selenium |x Therapeutic use. | |
| 650 | 0 | |a Selenoproteins. |0 http://id.loc.gov/authorities/subjects/sh2004014372 | |
| 650 | 0 | |a Selenium in human nutrition. |0 http://id.loc.gov/authorities/subjects/sh85119700 | |
| 650 | 0 | |a Selenium |x Physiological effect. |0 http://id.loc.gov/authorities/subjects/sh85119691 | |
| 650 | 0 | |a Cancer |x Chemoprevention. |0 http://id.loc.gov/authorities/subjects/sh92002505 | |
| 650 | 7 | |a Cancer |x Chemoprevention. |2 fast | |
| 650 | 7 | |a Selenium in human nutrition. |2 fast | |
| 650 | 7 | |a Selenium |x Physiological effect. |2 fast | |
| 650 | 7 | |a Selenium |x Therapeutic use. |2 fast | |
| 650 | 7 | |a Selenoproteins. |2 fast | |
| 700 | 1 | |a Brigelius-Flohé, Regina, |e editor. |0 http://id.loc.gov/authorities/names/nb2006004921 |1 http://isni.org/isni/0000000116762702 | |
| 700 | 1 | |a Sies, H. |q (Helmut), |d 1942- |e editor. |0 http://id.loc.gov/authorities/names/n82125651 |1 https://id.oclc.org/worldcat/entity/E39PBJqw3rqwjcJmG9YRW7DDv3 |1 http://isni.org/isni/0000000110813396 | |
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| 856 | 4 | 0 | |u https://colorado.idm.oclc.org/login?url=https://www.taylorfrancis.com/books/9780429161575 |z Full Text (via Taylor & Francis) |
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