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|a 1039519502
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|a 9780128016176
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|a GWRE
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|a QL959
|b .M36 2016eb
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| 245 |
0 |
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|a Mammalian Preimplantation Development /
|c edited by Melvin L. DePamphilis.
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| 264 |
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1 |
|a Cambridge, MA :
|b Academic Press is an imprint of Elsevier,
|c 2016.
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| 300 |
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|a 1 online resource (xxi, 455 pages, 32 unnumbered pages of plates :
|b illustrations (chiefly color))
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| 336 |
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|a text
|b txt
|2 rdacontent.
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| 337 |
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|a computer
|b c
|2 rdamedia.
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| 338 |
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|a online resource
|b cr
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| 490 |
1 |
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|a Current topics in developmental biology ;
|v volume 120.
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| 500 |
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|a Includes index.
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| 505 |
0 |
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|a Front Cover; Mammalian Preimplantation Development; Copyright; Contents; Contributors; Preface; 1. The Foundation of Mammalian Development; 2. The Unique Goals of Preimplantation Development; 3. The Events in Preimplantation and Peri-Implantation Development; 4. Recent Advances; 5. The Future of Preimplantation Development; 5.1. Genetic Diagnosis; 5.2. Genetic Intervention; 6. Cancer Stem Cells; References; Chapter One: Regulation of the Embryonic Cell Cycle During Mammalian Preimplantation Development; 1. Introduction; 1.1. The Somatic Cell Cycle; 2. The Preimplantation Cell Cycle.
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| 505 |
8 |
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|a 2.1. Preparation for the First Cell Cycle2.2. Initial Embryonic Cell Cycles; 2.3. Maternal-Zygotic Transition, Genome Activation, and Epigenetic Reprogramming; 2.4. Blastocyst Formation and Compaction; 2.5. Late Preimplantation; 3. Regulation of the Preimplantation Cell Cycle; 3.1. Cdks and Cyclins; 3.2. Cellular Regulation of Cdk/Cyclin Complexes; 4. Mouse Models of Cell Cycle Regulators as Developmental Tools; 4.1. Cell Cycle-Related Cdk/Cyclin Complexes; 4.1.1. Cdk4/Cdk6; 4.1.2. D-Type Cyclins; 4.1.3. Cdk2; 4.1.4. The E-Type Cyclins; 4.1.5. The A-Type Cyclins; 4.1.6. Cdk1.
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| 505 |
8 |
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|a 4.1.7. B-Type Cyclins4.1.8. Summary of Cell Cycle-Driving Cdks/Cyclins; 4.1.9. Cdk-Activating Kinase; 4.2. The Retinoblastoma and Related Pocket Proteins; 4.3. The E2F Family as a Downstream Target of Cdk/Cyclin Complexes; 4.4. Cdk3/Cyclin C; 4.5. Cdks and Transcription; 4.5.1. Cdk7/Cyclin H and Cdk9/Cyclin T; 4.5.2. Cdk8/Cyclin C; 5. DNA Damage and Checkpoint Signaling in the Preimplantation Embryo; 5.1. G1/S Checkpoint; 5.1.1. Embryonic Dependence on Cell Cycle Checkpoint Proteins; 5.1.2. ATR; 5.1.3. ATM; 5.1.4. Chk1/2; 5.2. Effectors of the G2/M Checkpoint; 5.2.1. The Cdc25 Phosphatases.
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| 505 |
8 |
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|a 5.2.2. Wee1/Myt1 Kinases5.2.3. Polo-Like Kinase 1; 5.3. The Spindle Assembly Checkpoint; 5.3.1. Emi1; 6. Concluding Remarks; References; Chapter Two: Genome Duplication at the Beginning of Mammalian Development; 1. Basic Concepts; 1.1. Genome Duplication Is a Problem of Astronomical Proportions; 1.2. All Living Organisms Use the Replication Fork Paradigm; 1.3. Nuclear DNA Replication Begins in the Zygote; 1.4. The Same Replication Machinery Is Used from Zygote to Adult; 1.5. Not All Replication Origins Are Replicators; 2. Replication Origins Are Established in Two Steps.
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| 505 |
8 |
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|a 2.1. Prereplication Complex Assembly (Origin Licensing)2.2. Preinitiation Complex Assembly (Origin Activation); 3. The First Mitotic Cell Division Is Universal; 4. The Second Cell Division Distinguishes Mammals from Nonmammals; 4.1. Cell Cleavage Gives Way to Cell Growth; 4.2. Cell Cycle Checkpoints Are Acquired at Different Stages in Development; 4.3. DNA Methylation Patterns Inherited from Gametes Are Erased; 4.4. Activation of ZGE Does Not Depend on DNA Replication; 5. Replication Origins Are Developmentally Regulated; 5.1. The "Jesuit Model" for Origin Selection.
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| 546 |
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|a Text in English.
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| 588 |
0 |
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|a Online resource; title from PDF title page (ScienceDirect, viewed August 8, 2016)
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| 650 |
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|a Mammals
|x Development.
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| 650 |
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0 |
|a Mammals
|x Growth.
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| 650 |
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0 |
|a Mammals
|x Reproduction.
|0 http://id.loc.gov/authorities/subjects/sh85080271.
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| 650 |
|
7 |
|a Mammals
|x Development.
|2 fast
|0 (OCoLC)fst01006966.
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| 650 |
|
7 |
|a Mammals
|x Growth.
|2 fast
|0 (OCoLC)fst01006985.
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| 650 |
|
7 |
|a Mammals
|x Reproduction.
|2 fast
|0 (OCoLC)fst01007009.
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| 700 |
1 |
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|a DePamphilis, Melvin L.,
|e editor.
|0 http://id.loc.gov/authorities/names/nr93040160
|1 http://isni.org/isni/0000000116158505.
|
| 776 |
0 |
8 |
|i Print version:
|t Mammalian preimplantation development.
|b First edition.
|d Amsterdam : Elsevier/Academic Press, 2016
|z 9780128014288
|w (OCoLC)950449885.
|
| 830 |
|
0 |
|a Current topics in developmental biology ;
|v v. 120.
|0 http://id.loc.gov/authorities/names/n42008732.
|
| 856 |
4 |
0 |
|u https://colorado.idm.oclc.org/login?url=https://www.sciencedirect.com/science/bookseries/00702153/120
|z Full Text (via ScienceDirect)
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