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|a RE551
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|a Retinal pigment epithelium in health and disease
|h [electronic resource] /
|c Alexa Karina Klettner, Stefan Dithmar, editors.
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| 260 |
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|a Cham :
|b Springer,
|c 2020.
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| 300 |
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|a 1 online resource (351 pages)
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| 336 |
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|a text
|b txt
|2 rdacontent.
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|2 rdamedia.
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|a online resource
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|a Description based upon print version of record.
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0 |
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|a Intro -- Preface -- Contents -- About the Editors -- Part I: Physiological RPE Function -- 1: RPE Histopathology and Morphometry -- Introduction -- Normal Histology -- Cell Morphometry -- Pleomorphism, Polymegathism -- Spatial Distribution, Topography -- Pathology -- Age-Related Changes -- Degenerations -- Biometry-Related Changes -- Age-Related Macular Degeneration -- Retinal Dystrophies -- Proliferative Retinopathies -- Mitochondrial Diseases -- RPE Tumors -- References -- 2: RPE Polarity and Barrier Function -- Introduction.
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| 505 |
8 |
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|a The Blood-Retinal Barrier (BRB) Is a Division of the Blood-Brain Barrier (BBB) -- Properties of a Blood-Tissue Barrier -- Epithelial Contributions to the Blood Retinal Barrier (BRB) -- Differentiation vs Maturation In Vivo and in Culture -- What Is an RPE Cell? -- Maturation of RPE Barrier Function in Chick Embryos and Small Mammals -- Maturation of RPE Barrier Function in Humans -- The Structure of Tight Junctions and Pathways for Solutes to Traverse Them -- Protein Composition -- Claudins Are Major Determinants for the Selectivity and Permeability of Tight Junctions.
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| 505 |
8 |
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|a Claudins Regulate Additional Pathways of Barrier Function Through Effects on Gene Expression -- Analysis of Paracellular Barrier Function -- Permeation of Polymeric Solutes -- Electrophysiological Assays -- Analysis of RPE Tight Junctions by Multiple Assays -- The Interplay of Tight Junctions and Membrane Transporters -- Retinal Pathology and RPE -- Conclusions -- References -- 3: RPE Phagocytosis -- Introduction -- Experimental Approaches to Quantify the Phagocytic Function of the RPE -- Molecular Mechanisms of RPE Phagocytosis -- Recognition and Binding of POS by RPE Cells.
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| 505 |
8 |
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|a Cell Surface Receptors and RPE Signaling Pathways Mediating POS Internalization -- Processing and Degradation of Phagocytosed POS by RPE Cells -- Defects in POS Clearance Phagocytosis by RPE Cells and Human Retinal Disease -- Outlook -- References -- 4: Ion Channels of the Retinal Pigment Epithelium -- Introduction -- Ionic Mechanisms of RPE Function -- Epithelial Transport -- Ion Channels That Contribute to Transepithelial Ion Transport by the RPE -- K+ Buffering in the Subretinal Space -- Ion Channels Contributing to the Control of Subretinal K+ Homeostasis.
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| 505 |
8 |
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|a Ca2+-Signaling to Regulate RPE Functions -- Secretion -- Epithelial Transport -- Phagocytosis -- Summary -- References -- 5: RPE and the Vascular Endothelial Growth Factor -- Vascular Endothelial Growth Factor -- RPE Derived VEGF Function in the Healthy Retina -- Development -- Adult Retina -- RPE Derived VEGF in the Diseased Retina -- Regulation of VEGF in the RPE -- Constitutive VEGF -- Hypoxia -- Oxidative Stress and Hyperglycemia -- Inflammation -- Hyperthermia -- Conclusion -- References -- 6: The RPE Cell and the Immune System -- Introduction -- RPE Cell: Role in Ocular Innate Immunity.
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| 500 |
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|a Components of Innate Immunity.
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| 650 |
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0 |
|a Retina
|x Pathophysiology.
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| 650 |
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0 |
|a Retina
|x Physiology.
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| 650 |
|
0 |
|a Epithelium.
|0 http://id.loc.gov/authorities/subjects/sh85044466.
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| 700 |
1 |
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|a Klettner, Alexa Karina.
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| 700 |
1 |
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|a Dithmar, S.
|q (Stefan)
|0 http://id.loc.gov/authorities/names/n2008183086
|1 http://isni.org/isni/000000003915725X.
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| 776 |
0 |
8 |
|i Print version:
|a Klettner, Alexa Karina
|t Retinal Pigment Epithelium in Health and Disease
|d Cham : Springer,c2020
|z 9783030283834.
|
| 856 |
4 |
0 |
|u https://colorado.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-28384-1
|z Full Text (via Springer)
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|a .b108926758
|b 05-05-20
|c 03-11-20
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|a MARS - RDA ENRICHED
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|a I
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|a Springer e-books
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|b Springer Nature - Springer Medicine eBooks 2020 English International
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|s 33c69687-f1fc-55f1-8b81-93fa6d5b9837
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|p Can circulate
|a University of Colorado Boulder
|b Online
|c Online
|d Online
|e RE551
|h Library of Congress classification
|i Ebooks, Prospector
|n 1
|
