Potentiation of opiate and psychostimulant reward by uncontrollable stress and the role of glucocorticoids [electronic resource]
Substance abuse does not typically develop in response to a single exposure to a drug, but rather to a combination of drug use and biological and/or environmental factors. Stress is one such factor that has been shown in both clinical and animal studies to facilitate the organism's initial resp...
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Online Access |
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| Format: | Thesis Electronic eBook |
| Language: | English |
| Published: |
2006.
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| Subjects: |
MARC
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| 100 | 1 | |a Der-Avakian, Andre. |0 http://id.loc.gov/authorities/names/no2004093666 |1 http://isni.org/isni/0000000048654637. | |
| 245 | 1 | 0 | |a Potentiation of opiate and psychostimulant reward by uncontrollable stress and the role of glucocorticoids |h [electronic resource] |
| 260 | |c 2006. | ||
| 300 | |a 174 pages. | ||
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| 500 | |a Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 1196. | ||
| 500 | |a Adviser: Steven F. Maier. | ||
| 502 | |b Ph.D. |c University of Colorado at Boulder |d 2006. | ||
| 520 | 3 | |a Substance abuse does not typically develop in response to a single exposure to a drug, but rather to a combination of drug use and biological and/or environmental factors. Stress is one such factor that has been shown in both clinical and animal studies to facilitate the organism's initial response to drugs of abuse, increasing the susceptibility for addiction. Indeed, there is a high comorbidity between stress-related disorders, such as major depressive disorder and post-traumatic stress disorder, and substance abuse, such that an acute, but traumatic, stressor can have enduring effects on subsequent drug use. Yet, the majority of animal studies have implicated only a transient role of acute stress on the response to drugs. The work presented here demonstrates that exposure to a single session of an uncontrollable, but not controllable, stressor can potentiate the rewarding effects of opiates and psychostimulants, even if the drug is administered long after the stressor and in a different environment. These effects appear to be mediated by glucocorticoid hormones (CORT), as the elevated CORT response to the drug, but not to the stressor, is necessary, but not sufficient, to produce the potentiated behavioral and neurochemical responses to morphine following exposure to uncontrollable stress. These results indicate that an acute, uncontrollable stressor can regulate the rewarding effects of drugs in a long-term, trans-situational manner, and implicate a critical role for CORT. | |
| 590 | |a School code: 0051. | ||
| 655 | 7 | |a Theses |x CU Boulder |x Psychology and Neuroscience. |2 local. | |
| 700 | 1 | |a Maier, Steven F., |e advisor. |0 http://id.loc.gov/authorities/names/n89614676 |1 http://isni.org/isni/0000000029783716. | |
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