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|a (TOE)ost10103411
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|a (TOE)10103411
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|a TOE
|c TOE
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|a E 1.99:doe/er/60658--4
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|a E 1.99:doe/er/60658--4
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|a Mutagenicity of radon and radon daughters. Annual progress report
|h [electronic resource]
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| 260 |
|
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|a Washington, D.C. :
|b United States. Dept. of Energy ;
|a Oak Ridge, Tenn. :
|b distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
|c 1991.
|
| 300 |
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|a 8 p. :
|b digital, PDF file.
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| 336 |
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|a text
|b txt
|2 rdacontent.
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| 337 |
|
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|a computer
|b c
|2 rdamedia.
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| 338 |
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|a online resource
|b cr
|2 rdacarrier.
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| 500 |
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|a Published through the Information Bridge: DOE Scientific and Technical Information.
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| 500 |
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|a 12/01/1991.
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| 500 |
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|a "doe/er/60658--4"
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| 500 |
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|a "DE92003695"
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| 500 |
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|a Evans, H.H.
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| 513 |
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|a Annual;
|b 12/31/1991.
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| 520 |
3 |
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|a The objective of our research is to investigate the dose-response relationship of the lethal and mutagenic effects of exposure of cells to radon and its decay products. Dose rate dependence and the nature of the DNA lesion will be studied, using the thymidine kinase and HPRT loci to measure mutation frequency. A deficiency in DNA repair is shown to lead to a greater proportion of mutants with intergenic lesions. The cytotoxic effects of radon and its daughters are similar in human TK6 lymphoblasts and mouse L5178Y lymphoblasts, the cell line used in previous experiments. The results of molecular analysis of four spontaneous and 25 X-radiation induced HPRT⁻ mutants. Eleven radon-induced HPRT⁻ mutants have been isolated, and will be analyzed in a similar fashion. 9 figs.
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| 536 |
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|b FG02-88ER60658.
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| 650 |
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|a Daughter Products.
|2 local.
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| 650 |
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|a Design.
|2 local.
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| 650 |
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7 |
|a Dosimetry.
|2 local.
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| 650 |
|
7 |
|a Progress Report.
|2 local.
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| 650 |
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7 |
|a Radiation Doses.
|2 local.
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| 650 |
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7 |
|a Mice.
|2 local.
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| 650 |
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7 |
|a Man.
|2 local.
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| 650 |
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7 |
|a X Radiation.
|2 local.
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| 650 |
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7 |
|a Animal Cells.
|2 local.
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| 650 |
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7 |
|a Biological Radiation Effects.
|2 local.
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| 650 |
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7 |
|a Radioisotope Generators.
|2 local.
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| 650 |
|
7 |
|a Gene Mutations.
|2 local.
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| 650 |
|
7 |
|a Radioinduction.
|2 local.
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| 650 |
|
7 |
|a Dose Rates.
|2 local.
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| 650 |
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7 |
|a Radon.
|2 local.
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| 650 |
|
7 |
|a Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat..
|2 edbsc.
|
| 710 |
2 |
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|a Case Western Reserve University.
|4 res.
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| 710 |
1 |
|
|a United States.
|b Department of Energy.
|4 spn.
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| 710 |
1 |
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|a United States.
|b Department of Energy.
|b Chicago Operations Office.
|4 res.
|
| 710 |
1 |
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|a United States.
|b Department of Energy.
|b Office of Scientific and Technical Information.
|4 dst.
|
| 856 |
4 |
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|u http://www.osti.gov/servlets/purl/10103411-uFvuXf/
|z Online Access
|
| 907 |
|
|
|a .b59845363
|b 03-06-23
|c 05-26-10
|
| 998 |
|
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|a web
|b 05-26-10
|c f
|d m
|e p
|f eng
|g dcu
|h 0
|i 1
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| 956 |
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|a Information bridge
|
| 999 |
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|s b12d885b-16f2-58e9-8e47-f17e807cd801
|
| 952 |
f |
f |
|p Can circulate
|a University of Colorado Boulder
|b Online
|c Online
|d Online
|e E 1.99:doe/er/60658--4
|h Superintendent of Documents classification
|i web
|n 1
|
