Discovery and biochemical evaluation of chemical probes for the study of jumonji-C domain containing histone demethylases and antibiotic resistance machinery in MRSA.
Part I: Histone demethylases (HDMs) are vital epigenetic regulators that have been implicated in multiple disease states including cancers. Demethylation catalyzed by jumonji-C domain-containing HDMs (JHDMs) is coupled to decarboxylation of alpha-ketoglutarate (alpha-KG). Based on this mechanism,...
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| Format: | Thesis eBook |
| Language: | English |
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Ann Arbor :
ProQuest Dissertations & Theses,
2015.
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