Congenital heart diseases : the broken heart : clinical features, human genetics and molecular pathways / Silke Rickert-Sperling, Robert G. Kelly, David J. Driscoll, editors.
This book provides comprehensive insights into congenital heart disease from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways. It is divided into three parts: an introduction to the development of the heart an...
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| Format: | eBook |
| Language: | English |
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Wien :
Springer,
[2015]
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Table of Contents:
- Foreword; Preface; Contents; Contributors; Abbreviations; Part I: Introduction; 1: Cardiac Development and Animal Models of Congenital Heart Defects; 1.1 Introduction; 1.2 From the Cardiac Crescent to the Embryonic Heart Tube; 1.3 Ballooning Morphogenesis and Cardiac Septation; 1.4 Development of the Conduction System and Coronary Circulation; 1.5 Animal Models of Heart Development; References; 2: Normal Cardiac Anatomy and Clinical Evaluation; 2.1 Introduction Normal Heart Anatomy; 2.1.1 Venous Return to the Heart; 2.1.2 Atria; 2.1.3 Atrioventricular Valves; 2.1.4 Ventricles.
- 2.1.5 Semilunar Valves2.1.6 Great Arteries; 2.1.7 Coronary Arteries; 2.1.8 Electrical System; 2.2 Techniques, History, and Physical Examination; 2.2.1 The History; 2.2.2 Physical Examination; 2.2.3 The Electrocardiogram; 2.2.4 Chest X-Ray; 2.2.5 Echocardiography; 2.2.6 Cardiac Catheterization; Part II: Development of the Heart and Its Vessels; 3: First and Second Heart Field; 3.1 Introduction and Historical Perspective; 3.2 The First Heart Field; 3.3 The Second Heart Field; 3.3.1 Regulation of Proliferation and Differentiation; 3.3.2 Patterning the SHF.
- 3.4 Non-myocardial Derivatives of the First and Second Lineages3.4.1 Endocardium, Epicardium and Vascular Endothelial and Smooth Muscle Cells; 3.4.2 Skeletal Muscles of the Head and Neck; Conclusion; References; 4: Neural Crest; 4.1 Introduction; 4.2 Overview of CNCC Derivatives; 4.3 Signaling Pathways Regulating Early CNCC Migration; 4.4 CNCCs and Pharyngeal Arch Artery Remodeling; 4.5 CNCCs and Septation of the Cardiac Outflow Tract and Valvulogenesis; 4.6 Role of Interaction of CNCCs and the Secondary Heart Field; 4.7 CNCCs in Cardiac Innervation and Conduction.
- 4.8 Failure of Outflow Septation: Persistent Truncus Arteriosus4.9 Examples of Human Syndromes with Defective CNCC Development; 4.9.1 22q11.2 Deletion Syndromes; 4.9.2 CHARGE Syndrome; 4.9.3 LEOPARD and Noonan Syndromes; Conclusion; References; 5: Inflow Tract Development; 5.1 Introduction; 5.2 Structures Found at the Venous Pole; 5.3 Development of the Venous Pole; 5.3.1 The Dorsal Mesocardium; 5.3.2 The Atrioventricular Cushions; 5.3.3 The Primitive Pulmonary Vein; 5.3.4 The Sinus Venosus; 5.3.5 The Dorsal Mesenchymal Protrusion; 5.3.6 The Components of the Atrial Septum.