Modulation of MHC antigen expression and disease / edited by G. Eric Blair, Craig R. Pringle & D. John Maudsley.

The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumour and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, vi...

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Bibliographic Details
Online Access: Full Text (via Cambridge)
Other Authors: Blair, G. Eric, Pringle, Craig R., Maudsley, D. John
Other title:Modulation of major histocompatibility complex antigen expression and disease
Format: Electronic eBook
Language:English
Published: Cambridge ; New York : Cambridge University Press, 1995.
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Description
Summary:The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumour and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression both in the aetiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumour rejection.
Physical Description:1 online resource (xviii, 440 pages) : illustrations
Bibliography:Includes bibliographical references and index.
ISBN:0521495784
9780521495783
0521499216
9780521499217
9780511525339
0511525338
DOI:10.1017/CBO9780511525339
Language:English.
Source of Description, Etc. Note:Source of description: Print version record.