Therapeutic applications of quadruplex nucleic acids [electronic resource] / Stephen Neidle.
New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no...
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Full Text (via ScienceDirect) |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
London ; Waltham, MA :
Elsevier/Academic Press,
2012.
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| Edition: | 1st ed. |
| Subjects: |
Table of Contents:
- Intro
- history and milestones
- Fundamentals of DNA and RNA quadruplex structure and stability
- Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance
- Genomic DNA and RNA quadruplexes
- involvement in gene expression and potential as therapeutic agents
- Quadruplex targets and human disease
- applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit
- Quadruplex ligands
- chemistry and design
- selectivity and assays
- Quadruplex ligands
- basic biology and assays indirect and direct
- Quadruplex ligands
- pharmacology and druggability, ligands in clinical trial and pre-clinical trial development
- Synthetic quadruplexes and drugs
- therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding
- Future directions and conclusions.